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Thesis Sahar El Aidy
The Dynamic Interplay of Microbiota and Mucosa Drives Establishment of Homeostasis in Conventionalized Mice
The link between gut microbiota, diet, metabolism, and immune system has been emphasized for many years. Nonetheless, there is still a gap in the information that explains the dynamics of the genetic regulations, which governs the interrelations between the gut microbiota and the metabolism, and how this in its turn affects the immune system. The work described in this thesis aimed at using germ-free animal models to explore the time- and region-dependent host response involved in metabolic and immune processes, while in parallel determine the establishment of the microbial community using microbial profiling methods during the time span of conventionalization. The major findings described in this thesis and their potential for future perspectives will be discussed in the following chapter to reach the overall objective of defining the molecular dynamics of host response to microbial colonization.