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Protein and physical activity to improve muscle health in men diagnosed with metastasized prostate cancer

 
luc van loon 90

Project leader: Prof Luc van Loon
Time frame: 2016 – 2020
Project code: 16 NH03
Research theme: Nutrition and Health
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 Summary


Because of the increasing prevalence of prostate cancer (PC) together with the increasing use of androgen deprivation therapy (ADT), preventing or limiting the negative consequences of ADT on body composition, becomes very important. ADT leads to an increase in fat mass (especially abdominal fat) and a decrease in muscle mass. Loss of muscle mass may contribute to fatigue, weakness, decreased physical performance, a lower level of independent living and a lower health related quality of life (HRQoL). Moreover, the increase in abdominal fat may enhance the risk of cardiovascular disease, diabetes and some other comorbidities. A substantial number of studies in patients with PC undergoing ADT show positive effects of exercise training on muscle mass, muscle strength, fatigue, physical performance, and HRQoL. Studies investigating the additional effect of dietary interventions, only explored the effect of a healthy or energy-restricted diet on body weight and fat mass. Although studies in healthy subjects and in frail elderly people show favorable additional effects of protein supplementation in combination with training on lean body mass, muscle strength and physical performance compared to training alone, no studies have assessed the impact of protein supplementation with exercise training in cancer patients. Therefore, the aim of the current study is to investigate if a combined intervention of resistance type exercise training (two 60 min exercise sessions per week for 4 months) with or without protein supplementation (20 g protein immediately after each exercise session, 30 g protein prior to sleep daily) is more effective to prevent or decrease the adverse effects of ADT on body composition in men with PC compared to resistance type exercise training with placebo supplementation or usual care. Primary study endpoints will be muscle mass, fat mass and body fat distribution. Secondary study endpoints will be muscle strength, physical performance, physical activity, level of independent living, nutritional intake, body weight, body height, HRQoL, fatigue, comorbidity and clinical laboratory tests. Measurements will be executed at baseline and after 4 months of intervention, and 8 months thereafter. This project will bring together key players in the nutrition industry and research institutes to evaluate the impact of protein supplementation to augment the benefits of exercise training and, as such, to develop novel concepts for protein enriched products and protein supplements both for the
clinical and the consumer market.
Key objectives

To define the benefits of resistance type exercise training with or without protein supplementation on body composition, functional capacity, and health in patients diagnosed with prostate cancer and treated with androgen deprivation therapy.

Main deliverables

  • Assessment of the impact of androgen deprivation therapy on muscle mass, muscle strength and metabolic health in patients diagnosed with prostate cancer.
  • Definition of the benefits of resistance type exercise training as a means to attenuate the decline in muscle mass, muscle strength and metabolic health in patients diagnosed with prostate cancer.
  • Definition of the benefits of protein supplementation to further augment the benefits of resistance type exercise training to attenuate or even prevent the decline in muscle mass, muscle strength and metabolic health in patients diagnosed with prostate cancer.