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Validation of biomarkers

 Top Institute Food & Nutrition - Annual Conference 2014, met uitreiking Joop Roels Impact Award

Project leader: Prof Cisca Wijmenga
Time Frame: 2011 – 2015
Project code: GH001
Research theme: Nutrition and health
Project login (project members only)

 


 Summary


There is an urgent need for established markers that reflect and predict gastrointestinal (GI) health. GI health is best defined as the absence of both disease and GI discomfort and the organism’s ability to return to homeostasis after a challenge, such as heavy exercise or a mild microbial infection.

This project aims to define signatures of a healthy gut. We test the validity of a set of existing single biomarkers and try to establish if new techniques such as metabolomics in exhaled breath, genomics and microbiomics can be used to identify signatures of biomarkers for a healthy gut. The focus is on easily-accessible biomarkers that can be monitored using a limited number of biological sample types such as stool, blood and exhaled breath, obtained from (prospective) cohorts of healthy subjects and from patients with functional GI disorders.

We collected extensive datasets covering more than 18,000 individuals from leading Dutch cohorts. We built our own sub-cohort, LifeLines-deep (LLDeep), which has 1,500 participants and supplied extra data for use in the project, and we also used data from 500 participants in the Maastricht-IBS (M-IBS) cohort.

At the end of the project the focus shifted to analysing the collected material and to correlating the relations between the existing single biomarkers, genetic backgrounds, exhaled breath and microbiome. A relation between all of these markers and GI health and intestinal integrity has been established.

 

Nurse With Patient During Health Check

 

Recent publications


Scientific papers in peer-reviewed journals Nieuwland, M., Bouwman, W.G., Bennink, M.L., Silletti, E., De Jongh, H.H.J. (2015) Characterizing length scales that determine the mechanical behavior of gels from crosslinked casein micelles. Food Biophysics 10, 416 - 427 View summary
Scientific papers in peer-reviewed journals Nieuwland, M., Bouwman, W.G., Bennink, M.L., Silletti, E., De Jongh, H.H.J. (2015) Characterizing length scales that determine the mechanical behavior of gels from crosslinked casein micelles. Food Biophysics 10, 416 - 427 View summary
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