- Considerable progress has been made with respect to modelling the pathways
and fluxes operative in the collective microbiota. The 16S rRNA-based stable
isotope probing analyses
indicate that certain species in the microbiota specifically ferment the
13C-labeled substrates and hint at a phenomenon of cross-fertilisation between
- Analyses of a clinical study with butyrate enemas in healthy volunteers have
indicated that butyrate increased the anti-oxidant potential of the epithelium
in terms of increased presence
of glutathione (GSH) and uric acid in biopsies from the rectal area of the GI
tract. This research has been awarded the Foppe ten Hoor-award.
- In a similar study, the effect of butyrate on pain-perception was studied.
The results showed a significant decrease in pain-perception after the butyrate
- In studying the health effect of the microbially produced metabolites on
adipocyte tissue (ex vivo), propionate was shown to decrease resistin, and
increase leptin production, two
hormones related to obesity. Interestingly, the magnitude of the effect
seemed to be correlated with the body-mass-index (BMI), in a way that the more
obese the volunteers from which
the adipocytes were obtained, the greater the decrease of resistin, and the
higher the increase of leptin, although the number of individuals studied was
still low. This points towards a
beneficial effect of propionate in the system (as opposed to local effects in
the GI tract).