Muscle health and function

lisette de groot 90

Project leader: Prof Lisette de Groot
Time frame: 2012 – 2015
Project code: MH001
Project login (project members only)




Muscle mass, strength, and physical performance are not only critical for athletic performance but also for healthy ageing and survival. Strategies which are considered effective in improving muscle growth and physical performance in athletes might be equally effective in countering loss of muscle mass and function in diseased and/or elderly people. Nutrition and exercise are considered the most effective measures to stimulate muscle growth and improve physical performance.


In this project, several acute and long-term human intervention trials were initiated to study 1) the impact of protein intake prior to sleep on subsequent overnight muscle-protein accretion, 2) the impact of vitamin D supplementation on physical performance in frail elderly people and 3) the anabolic properties of creatin to attenuate loss of muscle mass and strength during a period of muscle disuse. Gene-expression profiles and metabolic profiles in skeletal muscle tissue are being studied to reveal the mechanistic processes behind the (presumed) effects of novel nutritional strategies,

The project defined dietary strategies and novel nutritional concepts to enhance muscle mass and improve strength and physical performance. Populations likely to benefit most from these strategies include those aiming to improve sports performance and those most prone to loss of muscle mass and function due to immobilisation, disease and/or malnutrition.




Recent publications

Scientific papers in peer-reviewed journals 2015 The effect of exercise trianing on the course of cardiac troponin T and I levels: three independent training studies View summary
Scientific papers in peer-reviewed journals 2016 The muscle metabolome differs between healthy and frail older adults View summary
Scientific papers in peer-reviewed journals 2015 Handgrip strength does not represent an appropriate measure to evaluate changes in muscle strength during an exercise intervention program in frail older people View summary
Scientific papers in peer-reviewed journals 2015 Dietary protein intake in elderly people: A focus on protein sources View summary